D4I’s evaluation will seek to determine which approach—integrated or disease-focused—is more effective in improving health outcomes, with a focus on malaria outcomes. It will also seek to understand how effectively the different projects collaborate and coordinate to achieve desired outcomes and to understand synergies among the different projects in the portfolio. D4I will convene mission and partner stakeholders to develop a portfolio-level theory of change to identify how the projects are expected to work together in each state and will focus on the connections among projects and how they collaborate to achieve overarching goals. Real-time evaluation with local partners will provide feedback in collaborative learning sessions to translate results into program adaptations.